rs4680
rs4680 is the COMT Val158Met missense variant in catechol-O-methyltransferase, the enzyme that degrades synaptic dopamine, norepinephrine, and catechol estrogens. The Met allele reduces COMT enzymatic activity roughly three- to four-fold compared with Val, slowing catecholamine clearance and raising prefrontal dopamine tone. This activity difference underlies the Dopamine & catecholamines trait, covering dopamine signaling, stress reactivity, and estrogen-pathway processing.
Traits rs4680 reads
Gene
Reference databases
How Biome reads this
Biome's whole-genome test reads this from one saliva sample, alongside all 3.2 billion letters of your DNA.
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