IRF4
IRF4 encodes interferon regulatory factor 4, a transcription factor essential for lymphocyte differentiation (B cells, T cells, dendritic cells) that also regulates melanocyte gene expression, including modulating TYR (tyrosinase) transcription in pigment cells. The rs12203592 variant in an IRF4 enhancer is strongly associated with freckling, hair and eye color, and skin's tanning/sun-response behavior by altering melanocyte pigmentation output.
Traits IRF4 shapes
Markers (rsIDs)
Reference databases
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