AHR
AHR encodes the aryl hydrocarbon receptor, a ligand-activated transcription factor that senses dietary and environmental compounds and, on activation, dimerizes with ARNT to induce xenobiotic-metabolizing enzymes such as CYP1A1 and CYP1A2 in the liver. Because AHR helps switch on CYP1A2 expression, common variants near the gene (e.g., rs4410790) are among the most consistently replicated genome-wide hits for habitual caffeine and coffee intake.
Traits AHR shapes
Markers (rsIDs)
Reference databases
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